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Compounds from this group are often used for motion sickness, vertigo, nausea, and vomiting.The second-generation H receptors and cholinergic receptors.In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.Additional administration of epinephrine, often in the form of an autoinjector (Epi-pen), is required by people with such hypersensitivities.E-triprolidine, for example, is 1000-fold more potent than Z-triprolidine.This difference relates to the positioning and fit of the molecules in the histamine HThese compounds are structurally related to the ethylenediamines and the ethanolamines, and produce significant anticholinergic adverse effects.
The isomerism is a significant factor in the activity of the agents in this group.
Once released, the histamine can react with local or widespread tissues through histamine receptors.
Histamine, acting on H-antihistamines help against these effects, they work only if taken before contact with the allergen.
In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.
Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil.
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Desloratadine inhibited histamine release from human mast cells in vitro.